Influence of stress of a maternal organism on the turnover of catecholamines in the brain of early postnatal rats |
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Authors: | N D Nosenko |
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Institution: | (1) Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev, Ukraine |
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Abstract: | Effects of prenatal stress (daily 1-h-long immobilization of pregnant females at the 15th–21st days of pregnancy) on the formation
of sex-related dimorphism of the turnover of noradrenaline (NA) and dopamine (DA) in the preoptic area (POA) of the brain
and mediobasal hypothalamus (MBH) were studied in 10-day-old rats. Sex-related differences of the turnover of a functional
NA pool in the POA and DA pool in the MBH were demonstrated in intact control rats: a higher rate of the monoamine turnover
was observed in males. Prenatal stress abolished these sex-related differences and, at the same time, induced such differences
in the DA turnover in the POA. It is supposed that prenatal stress-evoked early modifications of sex-related dimorphism of
the catecholamine turnover in the brain can result in the development of remote disturbances in the neuroendocrine control
of reproduction and adaptation. |
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Keywords: | |
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