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Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection |
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| Authors: | Diane Ly Deborah Donahue Mark J Walker Victoria A Ploplis Jason D McArthur Marie Ranson Francis J Castellino Martina L Sanderson-Smith |
| Institution: | 1. Illawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia;2. W. M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States;3. School of Chemistry and Molecular Bioscience, Australian Infectious Diseases Research Centre, University of Queensland, St. Lucia, Queensland, Australia |
| Abstract: | Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA?/? mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease. |
| Keywords: | Corresponding author Illawarra Health and Medical Research Institute (IHMRI) School of Chemistry and Molecular Bioscience Molecular Horizons University of Wollongong Northfields Avenue Wollongong NSW 2522 Australia Fax: +61 2 4221 8130 Tissue-type plasminogen activator (tPA) Urokinase plasminogen activator (uPA) Plasminogen Streptokinase Animal infection model |
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