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Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion |
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| Authors: | Isaac S. Harris Jennifer E. Endress Jonathan L. Coloff Laura M. Selfors Samuel K. McBrayer Jennifer M. Rosenbluth Nobuaki Takahashi Sabin Dhakal Vidyasagar Koduri Matthew G. Oser Nathan J. Schauer Laura M. Doherty Andrew L. Hong Yun Pyo Kang Scott T. Younger John G. Doench William C. Hahn Sara J. Buhrlage Joan S. Brugge |
| Affiliation: | 1. Ludwig Cancer Center, Boston, MA 02115, USA;2. Harvard Medical School, Boston, MA 02115, USA;3. Dana-Farber Cancer Institute, Boston, MA 02115, USA;4. Boston Children’s Hospital, Boston, MA 02115, USA;5. Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA;6. Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA;7. Brigham and Women’s Hospital, Boston, MA 02115, USA |
| Abstract: |  |
| Keywords: | Corresponding author glutathione cancer oxidative stress deubiquitinase proteotoxic stress heat shock factor 1 HSF1 glutamate-cysteine ligase catalytic subunit GCLC high-throughput screening unfolded protein response UPR antioxidants |
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