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Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion |
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| Authors: | Isaac S Harris Jennifer E Endress Jonathan L Coloff Laura M Selfors Samuel K McBrayer Jennifer M Rosenbluth Nobuaki Takahashi Sabin Dhakal Vidyasagar Koduri Matthew G Oser Nathan J Schauer Laura M Doherty Andrew L Hong Yun Pyo Kang Scott T Younger John G Doench William C Hahn Sara J Buhrlage Joan S Brugge |
| Institution: | 1. Ludwig Cancer Center, Boston, MA 02115, USA;2. Harvard Medical School, Boston, MA 02115, USA;3. Dana-Farber Cancer Institute, Boston, MA 02115, USA;4. Boston Children’s Hospital, Boston, MA 02115, USA;5. Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA;6. Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA;7. Brigham and Women’s Hospital, Boston, MA 02115, USA |
| Abstract: |  |
| Keywords: | Corresponding author glutathione cancer oxidative stress deubiquitinase proteotoxic stress heat shock factor 1 HSF1 glutamate-cysteine ligase catalytic subunit GCLC high-throughput screening unfolded protein response UPR antioxidants |
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