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High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells |
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| Authors: | Chun-Mei Hu Sui-Chih Tien Ping-Kun Hsieh Yung-Ming Jeng Ming-Chu Chang Yu-Ting Chang Yi-Ju Chen Yu-Ju Chen Eva Y.-H.P. Lee Wen-Hwa Lee |
| Affiliation: | 1. Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan;2. Department of Pathology, National Taiwan University Hospital, Taipei 10041, Taiwan;3. Department of Internal Medicine, National Taiwan University Hospital, Taipei 10041, Taiwan;4. Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan;5. Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA;6. Drug Development Center, China Medical University, Taichung 40402, Taiwan |
| Abstract: |  |
| Keywords: | Corresponding author high glucose nucleotide imbalance O-GlcNAcylation RRM1 PFK KRAS mutation RNR |
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