Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis |
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Authors: | Mohamed A. Dkhil Mona F. Khalil Marwa S.M. Diab Amira A. Bauomy Simeon Santourlidis Esam M. Al-Shaebi Saleh Al-Quraishy |
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Affiliation: | 1. Department of Zoology, College of Science, King Saud University, Saudi Arabia;2. Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt;3. Department of Basic Sciences, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University, 1982 Dammam, Saudi Arabia;4. Molecular Drug Evaluation Department, National Organization for Drug Control & Research (NODCAR), Giza 12553, Egypt;5. Department of Laboratory Sciences, College of Science & Arts, Al-Rass, Qassim University, Buraydah, Saudi Arabia;6. Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany |
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Abstract: | Nanomedicine is one of the most important methods used to treat human diseases including parasitic diseases. Schistosomiasis is a major parasitic disease that affects human health in tropical regions. Whilst Praziquantel is the main classic antischistosomal drug, new drugs are required due to the poor effect of the drug on the parasite juveniles and immature worms, and the emergence of drug resistant strains of Schistosoma. The present study aimed to examine the curative roles of both gold and selenium nanoparticles on jejunal tissues of mice infected with Schistosoma mansoni. Transmission electron microscopy was used for characterization of nanoparticles. Gold nanoparticles of 1 mg/kg mice body weight and selenium nanoparticles 0.5 mg/kg body weight were inoculated separately into mice infected with S. mansoni. The parasite induced a significant decrease in glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly increased. Additionally, the parasite introduced deteriorations in histological architecture of the jejunal tissue. Treatment of mice with metal nanoparticles reduced the levels of body weight changes, oxidative stress and histological impairment in the jejunal tissue significantly. Therefore, our results revealed the protective role of both selenium and gold nanoparticles against jejunal injury in mice infected with S. mansoni. |
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Keywords: | Corresponding author at: Department of Zoology, College of Science, King Saud University, P.O. Box: 2455, Riyadh 11451, Saudi Arabia. Selenium nanoparticles Gold nanoparticles Schistosomiasis Jejunal injury Histopathology Oxidative stress Mice |
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