Efficacy of curcumin in the treatment of experimental vulvovaginal candidiasis |
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Authors: | Jessica Tauany Andrade Geisa Fantini de Figueiredo Luisa Ferreira Cruz Sarah Eliza de Morais Carla Daiane Ferreira Souza Flávia Carmo Horta Pinto Jaqueline Maria Siqueira Ferreira Marcelo Gonzaga de Freitas Araújo |
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Affiliation: | 1. Laboratory of Medical Microbiology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil;2. Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil;3. Natural Sciences Departament, Federal University of São João Del-Rei, Campus Dom Bosco, São João Del-Rei, Minas Gerais, Brazil |
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Abstract: | BackgroundCandida albicans is the main agent that causes vulvovaginal candidiasis. Resistance among isolates to azole antifungal agents has been reported.AimsDue to the well-known antifungal potential of curcumin, the purpose of this work was to evaluate the in vitro anticandidal activity of curcumin and its effect in the treatment of experimental vulvovaginal candidiasis.MethodsThe anticandidal activity of curcumin was investigated against eight Candida strains by the broth microdilution assay, and its mechanism of action was evaluated by testing the binding to ergosterol. Then, the effect of curcumin in the treatment of vulvovaginal candidiasis was evaluated in an immunosuppressed, estrogen treated rat model.ResultsCurcumin showed minimum inhibitory concentration values of 125–1000 μg/ml, and the best result was observed against Candida glabrata. The compound was shown to be able to bind to the ergosterol present in the membrane, event that may be the mechanism of action. In addition, in the in vivo model of vulvovaginal candidiasis with C. albicans, treatments reduced the vaginal fungal burden in infected rats after seven days of treatment with different doses.ConclusionsCurcumin could be considered a promising effective antifungal agent in the treatment of vulvovaginal candidiasis. |
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Keywords: | Corresponding author. Antifungal activity Curcumin Ergosterol Vulvovaginal candidiasis Actividad antifúngica Curcumina Ergosterol Candidiasis vulvovaginal |
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