| 肿瘤液态活检的研究进展及其临床应用 |
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| 引用本文： | 王晨,李艳明,方向东.肿瘤液态活检的研究进展及其临床应用[J].遗传,2017,39(3):220-231. |
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| 作者姓名： | 王晨 李艳明 方向东 |
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| 作者单位： | 1. 中国科学院北京基因组研究所,中国科学院基因组科学与信息重点实验室,北京 1001012. 中国科学院大学,北京 100049 |
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| 基金项目： | 国家自然科学基金项目(31471115,31401160,81670109) |
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| 摘 要： | 液态活检是一类新兴的病理检测手段,其研究内容包括肿瘤循环细胞、肿瘤循环DNA、外泌体等物质,其中的信息为肿瘤患者的个性化医疗提供有力的依据。它凭借无创、便捷等优势在临床应用中展现出广大前景。近年来,随着液态活检研究内容的扩大及其捕获与检测技术的发展,液态活检在临床中的应用日益广泛。本文旨在探讨近年来液态活检的主要研究对象、检测技术以及在临床应用中的发展前景与所面临的挑战,以期为肿瘤患者获得更佳的治疗,推动肿瘤精准医学的发展。
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| 关 键 词： | 液态活检 肿瘤循环细胞 肿瘤循环DNA 二代测序技术 |
| 收稿时间： | 2016-11-18 |
Research progress on liquid biopsy in oncology and its clinical applications |
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| Institution: | 1. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China2. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Liquid biopsy is an emerging and promising detection tool for cancer, with the benefit of being non-invasive and convenient. It analyzes tumor-derived information in the blood or other body fluids including circulating tumour cells (CTCs), circulating tumour DNA (ctDNA) and exosomes. Nowadays, with the expansion of liquid biopsy research contents and the development of capture and detection technologies, liquid biopsy is increasingly utilized in clinical applications, promoting the development of tumor precision medicine. Here, we mainly focus on reviewing the objects and technologies about liquid biopsy, as well as its applications, development and challenges in clinical practices. |
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| Keywords: | liquid biopsy CTCs ctDNA NGS |
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