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A Pilot Study on Neopterin Levels and Tryptophan Degradation in Zinc-Exposed Galvanization Workers |
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| Authors: | Elif Seyda Sarac Gözde Girgin S.Sezin Palabiyik Mohammad Charehsaz Ahmet Aydin Gönül Sahin Terken Baydar |
| Affiliation: | 1. Nanotechnology and Nanomedicine Division, Institute of Science, University of Hacettepe, Beytepe Campus, Ankara, Turkey 2. Department of Toxicology, Faculty of Pharmacy, University of Hacettepe, Sihhiye Campus, 90-06100, Ankara, Turkey 3. Department of Toxicology, Faculty of Pharmacy, University of Yeditepe, Istanbul, Turkey 4. Department of Toxicology, Faculty of Pharmacy, University of Eastern Mediterranean, Famagusta, TR North Cyprus 5. Nanotoxicology Group in Nanotechnology and Nanomedicine Division, Institute of Science, University of Hacettepe, Beytepe Campus, Ankara, Turkey |
| Abstract: | Hot-dip galvanization is a zinc-coating process to protect the metal items from corrosion. Zinc oxide nanoaerosol fume rising from hot metal bath surface in nano dimensions contains the greatest risk for workers in galvanization process. In the present study, it was evaluated whether inhalation of zinc causes any alteration in cellular immunity and tryptophan degradation by measuring neopterin, tryptophan, kynurenine, and zinc levels in 63 male galvanization workers and 23 male office personnel as controls. Serum and urinary zinc levels were found as 14.90?±?0.90 and 102?±?4.7 μg/dL in workers while 12.87?±?1.45 and 75?±?4.2 μg/dL in controls, respectively (both, p?p? |
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