Localization of the gene for Wieacker-Wolff syndrome in the pericentromeric region of the X chromosome |
| |
| Authors: | D-U Kloos S Jakubiczka T Wienker G Wolff P Wieacker |
| |
| Institution: | (1) Institute of Human Genetics, Otto von Guericke University, Leipziger Strasse 44, D-39120 Magdeburg, Germany Tel.: +49391 6715064; Fax: +49391 6715066, DE;(2) Max Delbrück Centre, Berlin, Germany, DE;(3) Institute of Human Genetics, Albert Ludwig University, Freiburg, Germany, DE |
| |
| Abstract: | The Wieacker-Wolff syndrome (WWS, MIM* 314580), first described clinically in 1985, is an X-linked recessive disorder. In
earlier studies, linkage between the WWS gene and DXYS1 at Xq21.2 and DXS1 at Xq11 as well as AR at Xq12 was reported. Here
we report on a linkage analysis using highly polymorphic, short terminal repeat markers located in the segment from Xp21 to
Xq24. No recombination between the WWS locus and ALAS2 or with AR (z = 4.890 at θ = 0.0) was found. Therefore, the WWS locus was assigned to a segment of approximately 8 cM between PFC (Xp11.3–Xp
11.23) and DXS339 (Xq11.2–Xq13).
Received: 14 March 1997 / Accepted: 9 April 1997 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
