| 肠道菌群失调对小鼠造血因子水平的影响 |
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| 引用本文： | 张琳,梁庆红,王沛,张亚超,骆金芝,王倩.肠道菌群失调对小鼠造血因子水平的影响[J].中国微生态学杂志,2004,16(3):138-139. |
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| 作者姓名： | 张琳 梁庆红 王沛 张亚超 骆金芝 王倩 |
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| 作者单位： | 1. 河北医科大学第三医院儿科,河北,石家庄,050051
2. 中国人民解放军白求恩军医学院,病原教研室,河北,石家庄,050051 |
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| 摘 要： | 目的:观察肠道菌群失调后小鼠造血因子水平的变化.方法:采用抗生素脱污染造成小鼠肠道菌群失调的动物模型,用ELISA的方法检测血清白细胞介素-3(IL-3)、粒-巨噬细胞集落刺激因子(GMCSF)的含量.结果:菌群失调后小鼠血清IL-3和GM-CSF的含量均低于对照组(P＜0.01);双歧杆菌数量与IL-3和GM-CSF含量存在显著正相关.结论:肠道菌群失调可影响机体造血功能.
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| 关 键 词： | 肠道正常菌群 菌群失调 造血因子 |
| 文章编号： | 1005-376X(2004)03-0138-02 |
| 修稿时间： | 2004年2月19日 |
Influence of intestinal dysbacteriosis on murine hemopoietic factor |
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| ZHANG Lin,LIANG Qing-hong,WANG Pei,et al..Influence of intestinal dysbacteriosis on murine hemopoietic factor[J].Chinese Journal of Microecology,2004,16(3):138-139. |
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| Authors: | ZHANG Lin LIANG Qing-hong WANG Pei |
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| Institution: | ZHANG Lin,LIANG Qing-hong,WANG Pei,et al . |
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| Abstract: | Obiective:To study the influence of dysbacteriosis on mice's hemopoietic factor.Methods:Animol models were made which have intestinal dysbacteriosis caused by antibiotics.Test the level of IL-3 and GM-CSF by ELISA.Results:Level of IL-3,GM-CSF have obviously decreased when compared with that in the control group( P <0.01).There were marked positive correlations between Bifidobacteria and the level of IL-3,GM-CSF.Conclusion:The results suggest that dysbacteriosis may decrease the hemopoietic function. |
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| Keywords: | Intestinal microflora Dysbacteriosis Hemopoietic facor |
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