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Synthesis and antiviral activity of L-2'-deoxy-2'-up-fluoro-4'-thionucleosides.
Authors:L S Jeong  H R Moon  S J Yoo  S N Lee  H D Kim  M W Chun
Affiliation:College of Pharmacy, Ewha Womans University, Seoul, Korea.
Abstract:L-2'-Deoxy-2'-up-fluoro-4'-thionucleosides were efficiently synthesized from D-xylose via L-4-thioarabitol derivative as a key intermediate and evaluated for antiviral activities against HIV-1, HSV-1,2 and HBV.
Keywords:
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