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Morphocytochemical and electron microscopic research on murine hybridoma cells producing and not producing monoclonal antibodies |
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| Authors: | S P Sidorenko D F Gluzman E P Vetrova O V Iurchenko A G Berdova |
| Abstract: | Cytochemical and ultrastructural features of mouse hybridomas and also of the parental cells--myeloma P3-X63-Ag8.653 and spleen cells of the Balb/c mice immunized with cell line RPMI-1788 have been studied. Differences in cytomorphological signs and activity of acid phosphatase, acid nonspecific esterase, nonspecific-alpha-naphthyl acetate esterase were shown in hybrid cell lines secreting and not secreting monoclonal antibodies. |
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