胰腺癌发病的分子机制和诊断

胰腺癌是高度恶性肿瘤，起病隐匿，早期诊断困难，临床疗效差，是预后最差的恶性肿瘤之一。目前临床上尚缺乏有效的非创伤早期筛查手段，多数患者确诊时已失去手术切除的机会。因此探讨胰腺癌发病的分子机制，特别是寻找在胰腺癌组织中高度特异性表达的基因，对于胰腺癌的早期诊断和治疗具有重要的意义。本文就胰腺癌发病的分子机制和早期诊断进行综述。

Molecular Mechanisms and Diagnosis of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma is one of most fetal malignancies and a genetic disease with historically limitedsuccess in treatment and a poor prognosis. Intensive useful molecules have been identified for diagnosis and treatment of the disease. Inthis review, we briefly summarize these molecular alternations of pancreatic cancer in order to understand the molecular mechanisms ofpancreatic cancer, which should not only promote development of new methodology for early diagnosis but also facilitate improvementapproaches for pancreatic cancer treatment in recently.