冠状动脉支架植入术后高凝状态的研究进展

支架内血栓形成是冠状动脉支架植入术后的重要并发症之一,尽管发生率较低,但严重者可危及生命。冠心病支架植入术后高凝状态源自患者的自身因素及支架植入所导致的一系列病理生理反应,包括斑块破裂、血管内皮损伤、组织因子大量表达、微粒生成增多等,进一步可激活血细胞和凝血系统,重者可导致局部血栓形成。及时检测及防治支架术后的高凝状态对降低支架内血栓的发生率有积极作用。本文主要对冠状动脉支架植入术后高凝状态的研究进展进行了综述。

Research Progress on the Hypercoagulable State after Coronary Stent Implantation

Stent thrombosis, despite the low incidence, is an important complication after coronary stent implantation, which can be life-threatening for the patients. Prothrombotic state results from patient''s own factors and a series of pathophysiological responses after stent implantation such as plaque rupture, vascular endothelial injury, tissue factor expression, increase of microparticles generation, activation of blood cells and coagulation system, and so on, which can result in severe local thrombosis. To reduce the incidence of stent thrombosis, timely detect and prevent the hypercoagulable state after stent implantation have veritable therapeutic potential. This article was aimed to review the research progress on the hypercoagulable state after coronary stent implantation.