成人原发肾病综合征患者血尿酸与血脂代谢的关系

目的:研究成人原发肾病综合征(PNS)患者高尿酸血症的患病率及其与血脂代谢的关系。方法:将109例成人PNS患者根据其尿酸水平分为高尿酸血症组与血尿酸正常组,检测患者的血脂、血清脂蛋白、ALB及24小时尿蛋白定量,分析成人PNS患者高尿酸血症的患病率,比较高尿酸血症组与血尿酸正常组PNS患者的一般情况及血脂水平,并分析PNS患者血尿酸水平的相关因素。结果:成人PNS患者高尿酸血症的发病率为24.77%;高尿酸血症组患者TG及24小时尿蛋白定量水平明显高于血尿酸正常组(P0.01),两组患者TC、LDL-C、HDL-C、Apo AI及Apo B比较差异无统计学意义(P0.05);成人PNS患者血尿酸水平与TG及24小时尿蛋白定量水平呈正相关(r=0.350,P=0.001;r=0.533,P=0.014),与TC、LDL-C、HDL-C及ALB无明显相关性(P0.05)。结论:成人PNS患者高尿酸血症的发生率较高,高尿酸血症患者具有更高的TG及尿蛋白水平,且成人PNS患者血尿酸水平与TG及24小时尿蛋白定量具有相关性,应高度重视成人PNS患者的血尿酸水平。

Relationship between the SerumUric Acid and Lipid Metabolismin Patientswith Adult Primary Nephrotic Syndrome

Objective:To investigate the prevalence rate of hyperuricemia and the relationship between serum uric acid and lipidmetabolism of patients with adult primary nephrotic syndrome (PNS).Methods:One hundred and nine patients with adult PNS wereselected and divided into hyperuricemia group and normal uric acid group. The levels of blood lipid, serum lipoprotein, albumin as wellas 24-hour urinary protein were evaluated. To investigate the prevalence of hyperuricemia among the patients diagnosed with primarynephrotic syndrome and to compare the general informations between the two groups. Meanwhile, the factors related to the level of serumuric acid were analyzed.Results:The incidence rate of hyperuricemia was 24.77% in patients with adult primary nephrotic syndrome.The levels of TG and 24-hour urinary protein in patients with hyperuricemia were significantly higher than those of the normal group(P<0.01). No significant difference was found in the serumlevels of TC, LDL-C, HDL-C, ApoAI and ApoB. The level of serum uric acidwas associated with the levels of TG and 24-hour urinary protein (r=0.350, P=0.001; r=0.533, P=0.014) instead of the levels of TC,LDL-C, HDL-C and ALB (P>0.05).Conclusion:The incidence rate of hyperuricemia was as high as 24.77%in patients with adult PNS.The levels of TG and 24-hour urinary protein in patients with hyperuricemia were significantly higher than those with normal uric acidlevel. The level of serum uric acid was associated with triglyceride as well as 24-hour urinary protein. We should pay more attention tothe level of serumuric acid in patients with PNS.