肾素-血管紧张素系统与子痫前期关系的研究进展

子痫前期是妊娠期特有的疾病。目前子痫前期的病因和发病机制尚未完全阐明，在其发生和发展过程中涉及到多种因素， 其中肾素- 血管紧张素系统（RAS）失调是子痫前期重要发病原因之一，参与子痫前期的病理生理学变化。本文就系统循环和子宫 胎盘RAS 各组分，尤其胃促胰酶(Chymase)和AT1 受体自身抗体（AT1-AA），在子痫前期的发生和发展中的变化和作用进行阐 述。

Advances in Research of Renin Angiotensin SystemwithPreeclampsia

Preeclampsia is a specific disease of pregnancy. The etiology and pathogenic mechanisms are not elucidated largely. Several factors are involved in preeclampsia, and highlighting the imbalance of renin-angiotensin system (RAS) is one of important reasons and participates in the pathophysiologic changes of preeclampsia. The article is aimed to review the changes and functions of the components of RAS in systemic circulation and uteroplacental unit, particularly chymase and AT1 autoantibodies (AT1-AA) in preeclampsia.