siRNAs targeting mouse myostatin |
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| Authors: | V. A. Furalyov I. V. Kravchenko V. P. Khotchenkov V. O. Popov |
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| Affiliation: | (1) Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 33, 119071 Moscow, Russia |
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| Abstract: | Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively. The obtained siRNAs can be used for study of biological effects of myostatin, both in vitro and in vivo. |
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| Keywords: | myostatin siRNA RNA interference myoblasts |
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