Hydrogenosomal succinate thiokinase in Tritrichomonas foetus and Trichomonas vaginalis |
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Authors: | T M Jenkins T E Gorrell M Müller P D Weitzman |
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Institution: | Rockefeller University, New York, NY 10021. |
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Abstract: | Succinate thiokinase displays a diversity of nucleotide specificity and molecular size throughout Nature. Eukaryotes and Gram-positive bacteria possess distinct 'small' (dimeric) thiokinase enzymes which are specific for adenine (ADP) or guanine (GDP) nucleotides, whereas Gram-negative bacteria contain a single 'large' (tetrameric) enzyme which utilizes both nucleotides. Succinate thiokinase activities, both ADP- and GDP-dependent, were shown to be hydrogenosomal in Tritrichomonas foetus and Trichomonas vaginalis. Surprisingly, the 'small' enzyme was found in T. foetus whereas T. vaginalis contained a 'large' enzyme. |
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