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Distribution of enteric neural peptide YY in the dog gastrointestinal tract |
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| Authors: | Keigo Iesaki Takafumi Sakai Minoru Satoh Norihiro Haga Haruko Koyama Zen Itoh |
| Affiliation: | a Gastrointestinal Research Laboratories, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan b Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan |
| Abstract: | Various regions of the dog gastrointestinal tract were investigated for the distribution of peptide YY (PYY) neurons using immunocytochemistry and radioimmunoassay. PYY neurons that encircled non-PYY-immunoreactive neurons were mainly observed in the myenteric plexus from the stomach to the colon. There was more PYY-like immunoreactivity in the muscle layer of the stomach and ileum than in the other intestines. The results of high performance liquid chromatography revealed that neural PYY-immunoreactive substance is identical to authentic PYY. PYY was not localized in the cholinergic neurons. These results indicate that PYY, as a neuropeptide, is involved in the regulation of gastrointestinal function. |
| Keywords: | Peptide YY (PYY) Dog Choline acetyltransferase (ChAT) Myenteric plexus Immunocytochemistry Radioimmunoassay (RIA) Noncholinergic enteric neurons |
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