Analysis of genetic heterogeneity in the HCAR adenovirus-binding Ig1 domain in a Caucasian Flemish population |
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| Authors: | Inge?Thoelen Griet?Duson Elke?Wollants Email author" target="_blank">Marc?Van RanstEmail author |
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| Institution: | 1.Laboratory of Clinical & Epidemiological Virology, Department of Microbiology & Immunology,Rega Institute for Medical Research, University of Leuven,Leuven,Belgium |
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| Abstract: | Background Polymorphisms in the gene that encodes the human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) could be responsible for differences in susceptibility to infections with these pathogens. Moreover, adenovirus subgroup C-mediated gene therapy could be influenced by mutations in the coding exons for the aminoterminal immunoglobulin-like 1 (Ig1) domain, which is the essential component for adenovirus fiber knob binding. |
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