| Affiliation: | (1) Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia;(2) State Brain Research Institute, Russian Academy of Medical Sciences, 105064 Moscow, Russia |
| Abstract: | Current data on glutamate-induced functional and morphological changes in mitochondria correlating with or being a result of their membrane potential changes are reviewed. The important role of Ca2+, Na+, and H+ in the potentiation of such changes is considered. It is assumed that glutamate-induced loss of mitochondrial potential is mediated by Ca2+ overload resulting in the induction of nonspecific permeability of the inner mitochondrial membrane.__________Translated from Biokhimiya, Vol. 70, No. 6, 2005, pp. 741–750.Original Russian Text Copyright © 2005 by Isaev, Andreeva, Stel’mashuk, Zorov. |
