Evidence for a second class of <i>S</i>-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria

Authors:	Keith A Corbino Jeffrey E Barrick Jinsoo Lim Rüdiger Welz Brian J Tucker Izabela Puskarz Maumita Mandal Noam D Rudnick and Ronald R Breaker

Institution:	(1) Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA;(2) Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA;(3) Department of Chemistry, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA;(4) Department of Physics, University of California, Berkeley, CA 94720-7200, USA

Abstract:	Background Riboswitches are RNA elements in the 5' untranslated leaders of bacterial mRNAs that directly sense the levels of specific metabolites with a structurally conserved aptamer domain to regulate expression of downstream genes. Riboswitches are most common in the genomes of low GC Gram-positive bacteria (for example, Bacillus subtilis contains examples of all known riboswitches), and some riboswitch classes seem to be restricted to this group.

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