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Mhc haplotype H6 is associated with sustained control of SIVmac251 infection in Mauritian cynomolgus macaques |
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| Authors: | Edward T Mee Neil Berry Claire Ham Ulrike Sauermann Maria T Maggiorella Frédéric Martinon Ernst J Verschoor Jonathan L Heeney Roger Le Grand Fausto Titti Neil Almond Nicola J Rose |
| Institution: | 1. Division of Retrovirology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK 2. German Primate Centre, Working Group Infection Models, Kellnerweg 4, 37077, G?ttingen, Germany 3. Division of Experimental Retrovirology and Non-Human Primate Models, National AIDS Center, Istituto Superiore di Sanità, Viale R. Elena 299, 00161, Rome, Italy 4. CEA, Division of Immuno-Virology, Institute of Emerging Diseases and Innovative Therapies, DSV, 18 route du Panorama, F-92265, Fontenay aux Roses, France 5. Université Paris-Sud, 11, UMR-E01, Orsay, France 6. Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ, Rijswijk, The Netherlands 7. Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK |
| Abstract: | The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of SIV in this species. Using microsatellite-based genotyping and allele-specific PCR, Mhc haplotypes were deduced for 35 macaques infected with the same stock of SIVmac251. Class I haplotype H6 was associated with a reduction in chronic phase viraemia (p = 0.0145) while a similar association was observed for H6 class II (p = 0.0063). An increase in chronic phase viraemia, albeit an insignificant trend, was observed in haplotype H5-positive animals. These results further emphasise the value of genetically defined populations of non-human primates in AIDS research and provide a foundation for detailed characterisation of MHC restricted cellular immune responses and the effects of host genetics on SIV replication in cynomolgus macaques. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
| Keywords: | Non-human primate Macaca fascicularis Genotype AIDS SIV |
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