| 异种移植的病毒安全性研究进展 |
| |
| 引用本文： | 马玉媛,杨勇贤,章金刚.异种移植的病毒安全性研究进展[J].中国实验动物学报,2008,16(6):463-469. |
| |
| 作者姓名： | 马玉媛 杨勇贤 章金刚 |
| |
| 作者单位： | 国家生物医学分析中心病毒安全检测实验室,军事医学科学院野战输血研究所,北京100850 |
| |
| 基金项目： | 国家科技支撑计划
，
国家自然科学基金
，
广西应用基础研究专项基金
|
| |
| 摘 要： | 猪-人异种移植有望解决人源器官短缺的严重问题。然而,以前病毒（provirus）形式整合入猪基因组中的猪内源性反转录病毒（porcine endogenous retrovirus,PERV）难以去除,PERV有可能通过异种移植传播给人类,甚至产生新的病毒性疾病。本文回顾了PERV与异种移植病毒安全性及我国特有小型猪中PERV的相关研究。
|
| 关 键 词： | 异种移植 猪内源性反转录病毒 中国特有小型猪 |
Viral Safety Risks Posed by PERVs in Xenotransplantation |
| |
| MA Yu-yuan,YANG Yong-xian,ZHANG Jin-gang.Viral Safety Risks Posed by PERVs in Xenotransplantation[J].Acta Laboratorium Animalis Scientia Sinica,2008,16(6):463-469. |
| |
| Authors: | MA Yu-yuan YANG Yong-xian ZHANG Jin-gang |
| |
| Institution: | MA Yu-yuan,YANG Yong-xian,ZHANG Jin-gang(Laboratory for Viral Safety of National Centre of Biomedical Analysis,Institute of Transfusion Medicine,the Academy of Military Medical Sciences,Beijing 100850,China) |
| |
| Abstract: | Pig to human xenotransplantation could potentially alleviate the shortage of human organs.However,porcine endogenous retroviruses(PERVs) which are present in the germline of pigs as proviruses could hardly be eliminated.PERV would be transferred to the human recipient along with xenografts.In a worst-case scenario,this might result in the emergence of a new viral disease.This report reviewed research on viral safety risks posed by PERVs in xenotransplantation as well as research on PERV from Chinese miniatu... |
| |
| Keywords: | Xenotransplantation Porcine endogenous retrovirus Chinese miniature pigs |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
