A histidine kinase PmHHK1 regulates polar growth, sporulation and cell wall composition in the dimorphic fungus Penicillium marneffei |
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| Authors: | Feng Wang Juhong Tao Zhen Qian Song You Hui Dong Huan Shen Xiaoxun Chen Shengrong Tang Shuangxi Ren |
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| Affiliation: | aChinese National Human Genome Center at Shanghai, Shanghai 201203, China;bSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;cShanghai-Ministry Key Laboratory of Disease and Health Genomics, Shanghai 201203, China |
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| Abstract: | Penicillium marneffei is an important opportunistic dimorphic fungal pathogen that can cause fatal systemic mycosis in AIDS patients. To find new ways of overcoming infection, candidate virulence associated genes and virulence mechanisms are under intensive investigation. In the present study, we have examined the function of a novel P. marneffei histidine kinase gene (PmHHK1) using dsRNAi mediated by Agrobacterium tumefaciens. Our results showed that reduction of PmHHK1 expression produces significant changes in morphogenesis (including polarized growth), sporulation and cell wall composition. Two-component signaling systems are widespread in the eukaryotes outside the animal kingdom, and could be potential drug targets for antifungal chemotherapy. |
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| Keywords: | Cell wall Drug target Histidine kinase Polar growth Promoter RNA interference Sporulation |
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