Murine Stim1 maps to distal Chromosome 7 and is not imprinted |
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| Authors: | Maree L Overall Nigel J Parker Deborah L Scarcella Peter J Smith Marie Dziadek |
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| Institution: | (1) Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3052, Australia, AU;(2) Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia, AU |
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| Abstract: | STIM1 (GOK) maps to a region of human Chromosome (Chr) 11p15.5 that is implicated in several embryonal tumors, and some evidence
indicates that STIM1 may have a growth suppressor role in rhabdomyosarcoma. In this study we have mapped the murine homolog,
Stim1, to the same position as Hbb on distal mouse Chr 7. This region is separated by 20 cM from the region of distal Chr 7 that contains Igf2, H19, and other imprinted genes. Using strain-specific polymorphisms, we have shown that Stim1 is expressed from both parental alleles in fetal and neonatal mouse tissues. Similar analyses of human Wilms' tumor and normal
kidney tissues demonstrated biallelic expression of STIM1 in the majority of samples. These data demonstrate that Stim1 expression is not regulated by genomic imprinting in either mouse or human tissues. Thus, if STIM1 is a tumor suppressor
at 11p15.5, loss of expression is not due to imprinting effects.
Received: 23 January 1998 / Accepted: 10 April 1998 |
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