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The influence of androgen administration on the structure and function of the brain-pituitary-gonad axis of sexually immature platyfish,Xiphophorus maculatus
Authors:Martin P. Schreibman  Henrietta Margolis-Nunno  Leslie R. Halpern-Sebold  Henk J. Th. Goos  Philip W. Perlman
Affiliation:(1) Department of Biology, Brooklyn College, City University of New York, Brooklyn, USA;(2) Zoological Laboratory, State University of Utrecht, Utrecht, The Netherlands;(3) Department of Biology, Brooklyn College, City University of New York, 11210 Brooklyn, NY, USA
Abstract:Summary This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early-and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocytochemical evaluation, increases the number and activity of pituitary gonadotropes, stimulates the production of sperm and, thus, advances the age of sexual maturation over that dictated by the genome. We also show that 11-KT and T affect different LHRH-containing centers in the brain and have differential effects on rate and degree of sexual maturation, regardless of whether the hormones are administered to early or late-maturing genotypes.
Keywords:Brain  Pituitary  Gonad  Androgens  Platyfish, Xiphophorus maculatus
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