Supramolecular complexing of membane Siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM |
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| Authors: | Cui Lina Kitov Pavel I Completo Gladys C Paulson James C Bundle David R |
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| Institution: | Department of Chemistry, Alberta Ingenuity Centre for Carbohydrate Science, University of Alberta , Edmonton, Alberta, Canada. |
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| Abstract: | We report the synthesis and in vitro evaluation of a multivalent homing device, a polymer which contains preordered pendant groups with dual specificity, a trisaccharide moiety, which is specific for the siglec CD22, and an antibody specific hapten, nitrophenol. The device efficiently attracts antihapten IgM to the surface of human lymphoma B cells as well as to CD22-conjugated magnetic beads by mediating the formation of a ternary complex on the surface of the target. |
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