In vitro effect of phencyclidine and other psychomotor stimulants on serotonin uptake in human platelets |
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| Authors: | R C Arora H Y Meltzer |
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| Affiliation: | 1. Illinois State Psychiatric Institute, 1601 W. Taylor St., Chicago, Illinois 60612, USA;2. University of Chicago Pritzker School of Medicine Department of Psychiatry, Chicago, IL 60637, USA |
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| Abstract: | Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake. Phencyclidine (IC50, 2.5 μM) was one-hundredth as potent as fluoxetine (IC50, 22 νM) but ten times more potent than ketamine (IC50, 25 μM) and d-amphetamine (IC50, 24 μM) and three times more potent than 1-amphetamine (IC50, 80 μM) in inhibition of 5-HT uptake by human blood platelets. The possibility that inhibition of 5-HT may contribute to some of the proposed serotonergic effects of psychomotor stimulants is discussed. |
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