Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae) |
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| Authors: | Asano N Nishida M Miyauchi M Ikeda K Yamamoto M Kizu H Kameda Y Watson A A Nash R J Fleet G W |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. naoki22@po.incl.ne.jp |
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| Abstract: | Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM). |
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