| 人类基因组信息量的扩增速率受重组的影响 |
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| 引用本文： | 刘国庆,罗辽复. 人类基因组信息量的扩增速率受重组的影响[J]. 生物化学与生物物理进展, 2012, 39(4): 368-377 |
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| 作者姓名： | 刘国庆 罗辽复 |
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| 作者单位： | 内蒙古科技大学;内蒙古大学 |
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| 基金项目： | 国家自然科学基金(61102162, 90403010), 内蒙古自治区高等学校科学研究项目(NJ10098)和内蒙古科技大学创新基金(2009NC005)资助项目 |
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| 摘 要： | 减数分裂重组是基因组进化的重要驱动力，揭示基因组在与重组有关进化压力下的进化规律是基因组进化研究领域的重要课题．一系列证据表明基因组编码信息量在进化过程中随时间增加．重组率与自然选择效率成正比，因此，在进化过程中基因组信息量的增加速率可能会受到重组率的影响．本文定义表征编码信息量增加速率的信息参数，以人类基因组为研究对象，分析基因组信息量的增加速率与重组率的关系，发现二者显著正相关，表明重组可能是加快基因组信息量增长的重要途径．
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| 关 键 词： | 重组率，编码信息量，信息增量，选择压力 |
| 收稿时间： | 2011-06-09 |
| 修稿时间： | 2012-01-04 |
The Growing Rate of The Information Quantity of The Human Genome is Modulated by Recombination |
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| LIU Guo-Qing and LUO Liao-Fu. The Growing Rate of The Information Quantity of The Human Genome is Modulated by Recombination[J]. Progress In Biochemistry and Biophysics, 2012, 39(4): 368-377 |
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| Authors: | LIU Guo-Qing and LUO Liao-Fu |
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| Affiliation: | 1) School of Mathematics,Physics and Biological Engineering,Inner Mongolia University of Science and Technology,Baotou 014010,China; 2) Institute of Bioengineering and Technology,Inner Mongolia University of Science and Technology,Baotou 014010,China; 3) School of Physical Science and Technology,Inner Mongolia University,Huhhot 010021,China) |
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| Abstract: | Meiotic recombination is driver of genome evolution. It is important to explore the rule of genome evolution under the control of evolutionary pressure linked to recombination. The coding information quantity of a genome (CIQ) always grows during evolution. Recombination rate is proportional to selection efficiency, thus the growing rate of coding information quantity of a genome (GRCIQ) might be mediated by recombination rate. In this study, a parameter is defined to characterize GRCIQ , and the correlation between GRCIQ and recombination rate is analyzed in the human genome. The results show that there is a positive correlation between them, indicating recombination is likely to be an important pathway to increase GRCIQ . |
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| Keywords: | recombination rate coding information quantity information increment selection force |
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