Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability |
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| Authors: | Qifeng Jiang Renjian Huang Shaoxi Cai Chih-Lueh A Wang |
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| Affiliation: | (1) Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, 400044 Chongqing, China;(2) Boston Biomedical Research Institute, 64 Grove St, 02472 Watertown, MA, USA |
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| Abstract: | Background Migration of vascular smooth muscle cells (SMCs) from the media to intima constitutes a critical step in the development of proliferative vascular diseases. To elucidate the regulatory mechanism of vacular SMC motility, the roles of caldesmon (CaD) and its phosphorylation were investigated. |
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