Propionic acid fermentation by Propionibacterium freudenreichii CCTCC M207015 in a multi-point fibrous-bed bioreactor |
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| Authors: | Xiao-Hai Feng Fei Chen Hong Xu Bo Wu Jun Yao Han-Jie Ying Ping-Kai Ouyang |
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| Institution: | (1) State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing University of Technology, No. 5 Xinmofan Road, New Model Road No. 5, Nanjing, 210009, People’s Republic of China;(2) State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmaceutial Engineering, Nanjing University of Technology, No. 5 Xinmofan Road, Nanjing, 210009, People’s Republic of China;(3) Department of Biotechnology, School of Basic Medical Science, Nanjing Medical University, Hanzhong Road 140, Nanjing, 210029, People’s Republic of China; |
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| Abstract: | Propionic acid was produced in a multi-point fibrous-bed (MFB) bioreactor by Propionibacterium freudenreichii CCTCC M207015. The MFB bioreactor, comprising spiral cotton fiber packed in a modified 7.5-l bioreactor, was effective for
cell-immobilized propionic acid production compared with conventional free cell fermentation. Batch fermentations at various
glucose concentrations were investigated in the MFB bioreactor. Based on analysis of the time course of production, a fed-batch
strategy was applied for propionic acid production. The maximum propionic acid concentration was 67.05 g l−1 after 496 h of fermentation, and the proportion of propionic acid to total organic acids was approximately 78.28% (w/w).
The MFB bioreactor exhibited excellent production stability during batch fermentation and the propionic acid productivity
remained high after 78 days of fermentation. |
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