Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice |
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Authors: | Aditya N P Chimote Geetanjali Gunalan Karthigayan Banerjee Rinti Patankar Swati Madhusudhan Basavaraj |
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Institution: | Faculty of Pharmacy, Uttarakhand Technical University, Dehradun, Uttarakhand 248007, India. |
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Abstract: | Present communication deals with the docking study of hybrid phenyl thiazolyl-1,3,5-triazine analogues (1a-36d) on three selected different binding site viz., α, β and γ of wild type Pf-DFHR-TS. In admiration of excellent H-bond scoring, with regard to cycloguanil and to a large extent similar scoring with WR99210, compound 4a, 12b, 21c, 23c, 28d, 29d, 34d, and 35d were selected for in vitro antimalarial activity against 3D7 strain of Plasmodium falciparum. Findings from the study disclose that a significant correlation was exist between in vitro results and in silico prediction (r(2)=0.543). Furthermore, investigation of structure-activity relationships elucidate crucial structural requirement for site specific binding of ligands. |
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