POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells |
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Authors: | Bera Tapan K Walker Dawn A Sherins Richard J Pastan Ira |
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Affiliation: | Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. BeraT@mail.nih.gov |
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Abstract: | The POTE gene family encodes very closely related proteins that are highly expressed in testis and in many cancers. Recent studies indicate that the POTE proteins have a pro-apoptotic function. To examine if POTE is associated with cells that are undergoing apoptosis in testis, we determined the cellular location of POTE and of Cleaved Caspase-3 in testicular tissues from 26 azoospermic men. We found intense expression of POTE in round spermatids that are undergoing apoptosis, which are positive for Cleaved Caspase-3. This study suggests POTE may have a role in apoptosis in the human testis. |
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