Degradation of HeLa S3 cell chromatin by auromomycin and its chromophore |
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| Authors: | Frank Rauscher Gail Mueller Mary McHugh Terry Beerman |
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| Affiliation: | 1. Department of Experimental Therapeutics, Roswell Park Memorial Institute Buffalo, New York 14263 USA;2. Grace Cancer Drug Center, Roswell Park Memorial Institute Buffalo, New York 14263 USA |
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| Abstract: | The antitumor protein agent auromomycin was found to degrade chromatin structure primarily by inducing strand scissions in linker regions. The reaction was stimulated by dithiothreitol. The chromophore form of the drug caused similar effects on chromatin, but it appeared to function at a more rapid rate. There was no evidence that auromomycin could cause breakage in core regions of chromatin. |
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| Keywords: | To whom correspondence should be addressed. |
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