Fructose 2,6-bisphosphate levels are elevated in livers of genetically obese mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Fructose 2,6-bisphosphate levels are elevated in livers of genetically obese mice

Authors:	Thomas H. Claus Simon J. Pilkis

Affiliation:	1. American Cyanamid Co., Medical Research Division, Lederle Laboratories, Pearl River, NY 10965 USA;2. Department of Physiology, Vanderbilt University, Nashville, TN 37232 USA

Abstract:	Fructose 2,6-bisphosphate levels in freeze-clamped livers of $C57BL 6J$ $ob ob$ mice were 6-fold higher than the level in their lean (+/?) littermates. Overnight starvation reduced the hepatic level of this unique sugar diphosphate to 0.2 nmol/g in both the obese and lean mice. The elevated level in the obese mouse is consistent with the hyperinsulinemia of these animals.

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