Effect of cigarette smoking on high density lipoprotein phospholipids |
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Authors: | Karen M. Hegarty Lynn E. Turgiss John J. Mulligan Joanne E. Cluette Richard R. Kew David J. Stack Jerome L. Hojnacki |
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Affiliation: | Biochemistry Program, Department of Biological Sciences, University of Lowell, Lowell, Massachusetts 01854 USA |
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Abstract: | The effect of acute inhalation of cigarette smoke on high density lipoprotein (HDL) phospholipid composition in White Carneau pigeons was examined. Four treatments included: 1) Shelf Control birds fed a chow diet and retained in their cages; 2) Sham pigeons fed a cholesterol-saturated fat diet and exposed to fresh air by a smoking machine; 3) Low nicotine-low carbon monoxide (LoLo) animals also fed the cholesterol diet and exposed to low concentrations of these cigarette smoke products; and 4) High nicotine-high carbon monoxide (HiHi) birds fed the cholesterol diet and subjected to high concentrations of these inhalants. The cholesterol-fat diet caused an increase in the concentration of most HDL phospholipid classes. Exposure to the HiHi regimen resulted in an increase in the HDL cholesterol/phospholipid ratio and a reduction in the concentration of HDL phosphatidyl ethanolamine, phosphatidyl serine/inositol, sphingomyelin and lysophosphatidyl choline. Cigarette smoking may thus attenuate HDL's anti-atherogenic properties by altering surface phospholipid components. |
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Keywords: | HDL high density lipoproteins LoLo low nicotine-low carbon monoxide HiHi high nicotine-high carbon monoxide LCAT lecithin cholesterol acyl transferase |
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