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Occurrence in high concentrations of N1-acetylspermidine and sym-homospermidine in the hamster epididymis |
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| Authors: | Shigeru Matsuzaki Koei Hamana Keiko Imai Kenji Matsuura |
| Institution: | 1. Department of Physiology, Institute of Endocrinology, College of Medical Care and Technology, Gunma University, Maebashi 371, and JEOL Ltd, Akishima 196, Tokyo, Japan;2. Department of Pharmaceutical Chemistry, Institute of Endocrinology, College of Medical Care and Technology, Gunma University, Maebashi 371, and JEOL Ltd, Akishima 196, Tokyo, Japan |
| Abstract: | In mature hamster epididymis several unknown peaks were observed on our high-performance liquid chromatograms in addition to the common polyamines, putrescine, spermidine and spermine. Three of the peaks were identified as N1-acetylspermidine, N1-acetylspermine and sym-homospermidine by means of thin-layer chromatography, gas chromatography-mass spectrometry and acid hydrolysis. The concentrations of N1-acetylspermidine and sym-homospermidine were highest in the distal caput epididymidis among epididymal regions studied. This is the first report to show that sym-homospermidine occurs in mammalian tissues. |
| Keywords: | α-GPDH alpha-glycerophosphate dehydrogenase bGH bovine growth hormone con control EGTA GH growth hormone HEPES 4-(2-hydroethyl)-1-piperazinethanesulfonic acid hypox hypophysectomized OAA oxaloacetate RR ruthenium red T3 triiodothyronine TMPD Tx thyroparathyroidectomized |
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