Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in spontaneously hypertensive rat |
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Authors: | Fuminori Masugi Toshio Ogihara Atsuhiro Otsuka Shuichi Saeki Yuichi Kumahara |
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Institution: | Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, Osaka 553, Japan |
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Abstract: | Chemically synthesized 1-O-hexadecyl-2-O-acetyl--glycero-3-phosphocholine possessed the most potent hypotensive activity compared with bradykinin, prostagrandin E2 and I2 when 5 nano moles/kg body weight of each drug were administered intravenously in spontaneously hypertensive rat. The potency and the duration of hypotensive activity of 1-O-hexadecyl-2-O-acetyl--glycero-3-phosphocholine were dose dependent. Exogenous norepinephrine or angiotensin II showed pressor activity during the hypotensive action of 1-O-hexadecyl-2-O-acetyl--glycero-3-phosphocholine, but did not disturb the hypotensive pattern of this ether lipid. These may suggest that 1-O-alkyl-2-O-acetyl--glycero-3-phosphocholine plays an important role for the regulation of blood pressure. |
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Keywords: | G-3-PC PG prostagrandin MBP mean blood pressure SHR spontaneously hypertensive rat |
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