Effects of Monoamine Oxidase Inhibitors on Methamphetamine-Induced Stereotypy in Mice and Rats |
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Authors: | Tomohiro?Tatsuta Nobue?Kitanaka Email author" target="_blank">Junichi?KitanakaEmail author Yoshio?Morita Motohiko?Takemura |
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Institution: | (1) Department of Pharmacology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan;(2) Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663–8501, Hyogo, Japan |
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Abstract: | In male ICR mice, a single intraperitoneal administration of methamphetamine (METH) (10 mg/kg) induced stereotyped behavior
such as continuous sniffing, circling, and nail biting, reaching a plateau level 20 min after the injection. Subcutaneous
pretreatment with clorgyline, a monoamine oxidase (MAO)-A inhibitor, at a dose of 0.1 mg/kg 2 h prior to the drug challenge
significantly decreased the initial (first 20 min) intensity of stereotypies and increased the latency to onset. The effect
was not observed with either higher doses of clorgyline (1 and 10 mg/kg) or l-deprenyl, a MAO-B inhibitor, at doses of 0.1–10 mg/kg. In male Wistar rats, the inhibitory effect of clorgyline on METH-induced
stereotypy was not observed. Pretreatment of the mice with clorgyline (0.1 mg/kg) had no effect on apparent serotonin and
dopamine turnover in the striatum, although the higher doses of clorgyline (1 and 10 mg/kg) significantly decreased the turnover.
These results suggest that a low dose of clorgyline tends to increase the latency and decrease the intensity of stereotypies
induced by METH in a dopamine metabolism-independent manner in mice. |
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Keywords: | Clorgyline methamphetamine monoamine turnover species difference stereotypy |
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