Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: synthesis, characterization, and their interaction with plasmid DNA |
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Authors: | Li Qiang-Lin Huang Jun Wang Qin Jiang Ning Xia Chuan-Qin Lin Hong-Hui Wu Jiang Yu Xiao-Qi |
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Affiliation: | Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China. |
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Abstract: | The synthesis of macrocyclic polyamine monometallic complexes containing imidazolium salt groups was reported. Their interaction with pUC19 plasmid DNA was studied. The result showed that these complexes can catalyze the DNA cleavage with unprecedented reactivity under physiological conditions. |
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