Volume-based solvation models out-perform area-based models in combined studies of wild-type and mutated protein-protein interfaces

Background  

Empirical binding models have previously been investigated for the energetics of protein complexation (ΔG models) and for the influence of mutations on complexation (i.e. differences between wild-type and mutant complexes, ΔΔG models). We construct binding models to directly compare these processes, which have generally been studied separately.