Inhibition of satiety by a cholecystokinin antagonist is independent of gastric emptying |
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Authors: | S M Collins H P Weingarten |
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Institution: | 1. Intestinal Disease Research Unit, McMaster University Hamilton, Ontario, L8N 3Z5 Canada;2. Department of Psychology, McMaster University Hamilton, Ontario, L8N 3Z5 Canada |
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Abstract: | The ability of a cholecystokinin antagonist Proglumide to inhibit satiety induced by intraperitoneal injections of cholecystokinin octapeptide (CCK-OP) and bombesin was examined in rats equipped with chronic gastric cannulae. Both CCK-OP and bombesin significantly suppressed sham feeding. Proglumide administered alone did not alter sham feeding but it abolished the suppression of feeding induced by CCK-OP. In contrast, Proglumide did not inhibit the effect of a low dose of bombesin, but partially inhibited satiety induced by a high dose of bombesin, thus confirming our previous findings. These results indicate that the effect of Proglumide is independent of its recently described effects on gastric emptying in rat. |
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Keywords: | Cholecystokinin Proglumide Bombesin Sham feeding Satiety Gastric emptying |
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