Schwannoma-Derived Growth Factor Interacts with the Epidermal Growth Factor Receptor |
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| Authors: | Pamela A Maher David Schubert |
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| Institution: | Department of Molecular and Cellular Growth Biology, Whittier Institute for Diabetes and Endocrinology;and; The Salk Institute for Biological Studies, La Jolla, California, U.S.A. |
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| Abstract: | Abstract: Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF receptor but not HER2/neu. |
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| Keywords: | Phosphotyrosine Growth factors Epidermal growth factor |
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