Spontaneous excretion of D-alanine in urine in mutant mice lacking D-amino-acid oxidase. |
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| Authors: | R Konno Y Nagata A Niwa Y Yasumura |
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| Affiliation: | Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan. |
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| Abstract: | Urine from mutant mice lacking D-amino-acid oxidase contained a large amount of alanine compared with that from normal mice. Urinary alanine of the mutant mice was sensitive to D-amino-acid oxidase. H.p.l.c. showed that about 94% of the urinary alanine had the D-configuration. These results suggest that D-amino-acid oxidase functions to decompose D-amino acid(s) in normal mice. |
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