Contribution of signals and antisignals in the mutational spectrum of the td-intron insertion site] |
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| Authors: | M P Ponomarenko Iu V Ponomarenko N A Kolchanov |
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| Institution: | Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia. |
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| Abstract: | The insertion sites of the td-intron were studied. It was found that tetranucleotides W-30A-29W-28Y-27, V-19B-18W-17A-16 and A11W12A13W14 predominantly occur at normal sites (signals), and tetranucleotides Y-27W-26M-25G-24, V7B8W9A10 and Y15W16M17G18 occur more frequently at defective sites (antisignals). It was shown that antisignals make the site defective, by blocking its signals. The site becomes defective due to the distortion of signals at a large number of random substitutions, and due to antisignals when the substitutions are few. |
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