综述: 引发“战斗?鄄逃跑”反应的神经环路机制

"战斗-逃跑"反应是人和动物面临生存威胁时,产生的一系列应激行为和生理反应,该反应有助于个体提高战斗或逃跑的能力,以提高生存概率.过度或反复"战斗-逃跑"反应能诱发一类称为创伤后压力应激障碍(post-traumatic stress disorder,PTSD)的精神疾病.频繁的自然灾害和交通事故使我国人口受到PTSD的严重危害.要揭示PTSD的发病机理,首先需要深入地了解引发"战斗-逃跑"反应的脑内神经环路和机制.本文综述了该研究领域的进展和亮点工作,强调了该研究在国家相关领域中的重要性.

Review: Neural Circuit Mechanism Underlying Fight-or-flight Response

Fight-or-flight response is a series of behavioral and physiological reactions triggered by life-threatening stress. These reactions enable individuals to escape from or defend against environmental threats, thus increasing the survival rate in dangerous situations. Stong or repeated fight-or-flight response sometimes causes a type of mental disorder, namely post-traumatic stress disorder (PTSD). Frequent natural disasters and traffic accidents have endangered Chinese people with PTSD. PTSD treatment calls for understanding the fundamental neural circuit mechanisms underlying fight-or-flight response.In this review, we will summarize recent progress in this field, and emphasize the significance of this research field in the China.