| PIC—BE对K562／ADM多药耐药细胞mdr—1和bcl—2基因表达的影响 |
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| 引用本文： | 卢步峰,朱正美.PIC—BE对K562／ADM多药耐药细胞mdr—1和bcl—2基因表达的影响[J].实验生物学报,1999,32(2):121-125. |
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| 作者姓名： | 卢步峰 朱正美 |
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| 作者单位： | [1]中科院上海细胞所 [2]大连医科大学辽宁细胞分子生物学重点实验室 |
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| 摘 要： |
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| 关 键 词： | β－榄香烯吗素 多药耐药细胞株 mdr－1 bcl－2 |
Effect of PIC-BE on the expression of MDR-1 and bcl-2 genes in a multidrug resistance cell variant K562/ADM] |
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| B F Lu,Z M Zhu,L M Yu,C X Bian,P M Yang.Effect of PIC-BE on the expression of MDR-1 and bcl-2 genes in a multidrug resistance cell variant K562/ADM][J].Acta Biologiae Experimentalis Sinica,1999,32(2):121-125. |
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| Authors: | B F Lu Z M Zhu L M Yu C X Bian P M Yang |
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| Institution: | Key Laboratory of Cellular and Molecular Biology of Liaoning Province, Dalian Medical University, Dalian 116027. |
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| Abstract: | The effect of PIC-BE on the expression of mdr-1, bcl-2 and bax genes and their protein products (P-gp, Bcl-2 and Bax) was observed respectively in a multidrug resistance (MDR) cell variant K562/ADM. The results showed that PIC-BE could significantly inhibit the expression of mdr-1 and bcl-2 genes at both mRNA and protein levels in K562/ADM cell line, and the effect was dose- and time-dependent within limited range. Under same condition, although PIC-BE could increase the expression of Bax slightly, there was no statistically significant difference. These results suggest that the reversal of the MDR of K562/ADM cell line by PIC-BE may result from its effect on the expression of mdr-1, bcl-2 genes and their protein products. |
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